Chillicothe, MO Is Located At The Intersections Of Highways 36 & 65 In Northwest Missouri.

Chillicothe is approximately 98 miles from the K.C. International Airport or approximately 80 miles East of St. Joseph, MO.

Major interstates: I-70. I-35, I-29 connect with either 36 or 65 Highways.

• From Kansas City:  Go North on I-35 to Cameron. Turn East on Highway 36 to Chillicothe.

• From St Joseph, MO: Go East on Highway 36 to Chillicothe.

• From St Louis & Columbia: Go West on I-70 to the Marshall Junction. Go North on Highway 65 to Chillicothe.

• From Hannibal, MO: Go West on Highway 36 to Chillicothe.

• From Springfield, MO: Go North on Highway 65 to Chillicothe.

• From Iowa: Go South on Highway 65 to Chillicothe.